19th International Conference on Structural Biology

About Conference

On behalf of the Scientific Organising Committee, we are overwhelmed to welcome all the interested participants to attend the 19th International Conference on Structural Biology during September 28-29, 2020 at Barcelona, Spain.

The conference will be organized around the theme: An Insight into Every Dimension of Advanced Structural Biology Research

Structural Biology 2020 is a three-day event consisting of a lettered scientific program, laudable talks by the top-notch of the global scientific community, that brings together active researchers, intellectuals, academicians, students, contributors and industrialists to exchange ideas communicate and discuss research findings on new advancements in all kinds of available research worldwide innovative research products which can be exhibited for further development in Biochemistry. This Biochemistry Congress is going to be the largest and most promising international conference that specifically focuses on the Structural Biology by bringing all renowned researchers under one roof. This is a three-day multi-disciplinary meeting covering all aspects of novel research and contributions in the field of structural biology and biophysics.

Conference Highlights

Track 1: Structural Biology

Structural Biology is the branch of biology which embarks the importance of biophysics and biochemistry in the molecular structure of biological macromolecules. It also provides information about the effect of structural alterations of macromolecules on their function. This process of determination of structures of proteins, nucleic acids may take years as the shape, size and assemblies of these molecules may be altering the function.

Biochemistry
Structural modifications in nucleic acids
Biological system
Alternations in Protein Structure

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American Society for Cell Biology, American Society for Biochemistry and Molecular Biology, Association of South-Eastern Biologists, Federation of European Biochemical Societies, Royal Society of Biology, Society for Experimental Biology, International Society for Computational Biology, Society for Molecular Biology and Evolution, American Crystallographic Association, Belgian Society of Biochemistry and Molecular Biology, International Mass Spectrometry Foundation, International Union of Crystallography, European Society of Human Genetics, European Proteomics Association, European Molecular Biology Organization, African Society for Bioinformatics and Computational Biology, American Mass Spectrometry Society, Australasian Proteomics Society, Austrian Proteomics Society.

Track 2: Proteomics and Genomics

Proteomics is the newest and the most discussed topic in the field of Structural Biology. It deals with determining the structure and function of proteins- the building blocks of the human body. It found its importance after the introduction of the Human Genome Project. Almost every process that occurs in our cells – from the metabolization of simple sugar to the division of cells – is dependent on proteins for smooth operation.
Genomics is the study of structure, working, mapping and alteration of genomes. The entire arrangement of DNA- the information centre of our body is known as genomics. Proteomics and Genomics are interrelated. Proteomics involve the study of structural determination of the body whereas Genomics involve the study of genetic makeup of the body.

Chemical & single cell proteomics
Molecular and cellular proteomics
Expression proteomics
Quantitative proteomics
Post-translational modifications & signal transduction
Cancer Genomics
Clinical Genomics
Comparative Genomics
Functional Genomics

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Track 3: Biochemistry and Biophysics

Biochemistry is the study of chemical processes taking place inside the human body. Recently this subject has found its importance in the biological world as it has found its importance in all fields of life science and biology. By controlling information flow through biochemical signalling and the flow of chemical energy through metabolism, biochemical processes give rise to the complexity of life. Its main focus is to understand how biological molecules give rise to the processes that occur within living cells.

Biophysics is the trending topic in the field of biology. It relates physics and biology. In other words, it signifies how traditional physical methods are used to study the biological phenomena inside the human body. Biophysical research shares significant overlap with biochemistry, molecular biology, physical chemistry, physiology, nanotechnology, bioengineering, computational biology, biomechanics and systems biology.

Systems Biology
Metabolomics
Biomolecules
Biophysical approaches to cell biology
Membrane Biophysics
Computational and theoretical Biophysics
Computational and theoretical Biophysics

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Track 4: Molecular Biology

Molecular Biology is a vast topic which deals with the structure and function of macromolecules. It is usually combined with techniques of Genetics and Biochemistry. Till 2000, Molecular genetics was the sub-field of Molecular Biology. Since Molecular Biology is mostly quantitative it’s in edge with computational biology and bioinformatics. Other zones of Biology focus directly or indirectly on molecules, whereas developmental biology and cell biology focus directly, while phylogenetic and evolutionary biology focus indirectly. Genetics deals with study of mutants and its comparison with the wild type (normal phenotype).

Genetics
Cell Biology
Developmental Biology
Gene Expression

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Track 5: 3-D Structure Determination

Biomolecules are very small to see in detail even by most cutting-edge light microscopes. The methods that the structural biologists use to determine their structures in general involve the measurements on huge numbers of identical molecules at the same time. Some of the best methods include X-ray crystallography, cryo-electron microscopy and nuclear magnetic resonance. Apart from these methods there are many additional methods through which 3 D Structure Determination can be done.

X-ray crystallography
Nuclear Magnetic Resonances
Cryo-Electron Microscopy
Mass spectroscopy
Dual polarisation interferometry
Multi-angle light scattering Technique
Ultra-fast laser spectroscopy

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Track 6: Computational Approach in Structural Biology

Computational approaches are a boon for structural biology. These methods use the concepts of bioinformatics to determine the structure of macromolecules. In general, the structure of molecules is determined by experimental methods is both time intense and cost effective. To overcome these constraints, computational approaches like ab-initio modelling, homology modelling and threading method are used.

Homology modelling
Ab-initio method
Threading
Discoveries through computational approaches

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Track 7: Molecular Modelling and Dynamics

Molecular modelling involves the hypothetical and computational procedures which are used to mimic the behaviour of macromolecules. Molecular modelling techniques are used in various fields some of which are drug design, computational chemistry, materials science and computational biology. These methods are used for studying and understanding the properties of the molecules. One of the major applications of molecular modelling is molecular simulation. This is the technique which uses powerful lculatiocomputers to simulate the interactions between atoms and to understand the properties of materials. Such simulations involve methods that range from very detailed quantum mechanical cans on atoms to coarse-grained classical dynamics of large groups of molecules on a timescale of milliseconds or longer.

Molecular dynamics (MD) deals with the study of physical movements of the atoms and molecules using computer simulation method, so it is referred to as one of the type of N-body simulation. The atoms and molecules are allowed to interact for a fixed period of time, giving a view of the dynamic evolution of the system. The trajectories of atoms and molecules are commonly determined by solving them numerically using Newton’s equations of motion for a group of collaborating particles. The forces between the particles and their potential energies are calculated using inter-atomic potentials or molecular mechanics force fields.

Steered molecular dynamics (SMD)
Potentials in ab-initio methods
Hybrid QM/MM
Protein folding
Enzyme catalysis
Protein stability
Molecular recognition of proteins
DNA and membrane complexes

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Track 8: Drug Designing and Biomarkers

A biomarker is an attribute that can be studied as an indicator of pathogenic and biological operation along with pharmacological retort to a therapeutic involvement. They indicate either normal or diseased activity in the body. Biomarkers are specific molecules, genes, gene products, hormones, cells or enzymes.

Drug designing is an inventive process to find new medication centred on the knowledge of biological target. Drug is most commonly a small molecule that inhibits or activates the function of a biomolecule, which in turn outcomes in a therapeutic benefit to the patient. Drug design commonly but not essentially relies on computational techniques. This type of modelling is often mentioned to as computer-aided drug design.
Drug targets
Ligand-based design
Structure-based design
Computer-aided drug design
Scoring functions

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Track 9: Gene regulation and Cell Signalling

Signalling is the process through which the cells communicate with each other. They are often secreted from the cell and released into the extracellular space. Regulation of gene expression comprises a comprehensive range of mechanisms that are used by cells to regulate the production of specific gene products, and is familiarly termed as gene regulation. Sophisticated programs of gene expression are extensively observed in biology, for example to trigger developmental pathways, adapt to new food sources, or respond to environmental stimuli.

G-protein-coupled receptor
Adrenergic receptor
Protein crystallography
Protein structure

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Tracks 10: Structural Enzymology

Enzymes play a crucial role in signalling the cellular and metabolic pathways. Research works are going on to identify, how the enzymes function at molecular and atomic level by combining the modern and structural biology.

Protein engineering
Protein prenylation techniques
Steady state kinetics
Calorimetric methods
Chemical analysis

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Track 11: Sequencing Analysis

Sequence analysis can be explained as a process of exposing DNA, RNA or peptide sequence to a wide range of analytical methods in order to understand its structure, function and evolution. The methods include sequence alignment and biological databases. Synergistic use of three-dimensional structures and deep sequencing is done to realize the effect of personalized medicine. The usage of sequence analysis in structural biology will pave the way to new methods which can be utilized to determine the structure of molecules.

Profile comparison
Sequence assembly
Gene prediction
Deep sequencing for protein structure determination
Complementary Methods
Deep sequencing for cancer studies
Deep sequencing of HIV

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Track 12: Hybrid approaches in Structure prediction

This is a cost effective approach for determining the protein structure. The computational prediction methods, such as initiating fragment assembly, advanced fold recognition, composite approaches, and molecular docking are regularly applied in recent times to expand our understanding of protein structures. Hybrid approach is a channel to overcome these disadvantages, by incorporating limited experimental measurements, reliable structures can be computed, and unlikely predictions are eliminated. The current researches are showing great interest in this method of approach.

NMR structures
Hybrid of experimental methods
Hybrid of computational methods
Hybrid approaches in complementing high-resolution structural biology
Determining protein complex structures
Bottom-up integration of atomic detail crystallography

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Track 13: Structural Bioinformatics

Structural bioinformatics is an exceptionally cost-effective solution for protein structure determination. Purely computational prediction methods, like ab initio fragment assembly, advanced fold recognition, composite approaches, and molecular docking are regularly applied today to extend our understanding of protein structures. However, predicted structures are not given the same reliance as their experimental complements. Hybrid approaches are a means to overcome these limitations; by incorporating limited experimental measurements, reliable structures can be computed, and unlikely predictions eliminated. Hybrid approaches take advantage of data derived from a wide range of different biophysical and biochemical methods. These methods are of growing interest in current researches of structural biology.

Genome Mapping
Translational Medicine
Protein Modelling
Epigenomic data analysis
Computational Neuroscience
Mathematical Techniques

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Track 14: Frontiers in Structural Biology

The main focus of a structural biologist is protein structure determination and drug design. Protein plays an important role in human body. Living things would not exist without proteins. The proteins are usually involved in all forms of expressions of the living organism. Most of the proteins are evolved in providing structure to the cell while the others tend to bin and carry vital molecules all through the body. Some proteins are involved in biochemical reactions in the body which are termed as enzymes. Others are involved in muscle contractions and immunity. Structure determination of proteins has always been a challenging filed. The complex areas in the field include viruses, pathogens, membrane proteins and signalling pathways. Novel progressions are being done in the arenas of nano-patterning and multi-scale modelling of cell signalling proteins.

Membrane proteins
Pathogens and viruses
Nano patterning
Macromolecular designing

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Track 15: Structural Biology in Cancer Research

The main aim of integrating structural biology data into cancer research is to design and discover novel and effective drugs to cure the disease. Structural biology combined with molecular modelling mainly aims at drug designing. Consequently, a number of Structural Biologists are conducting cancer research, to speed-up the process of understanding the mechanism of biomolecules in order to improve the newer cancer therapies.

Major part of research is being carried out in the area of cancer. The main aim is to design and discover novel and effective drugs to cure the disease. Structural biology combined with molecular modelling mainly aims at drug designing. Subsequently, numerous team leaders in Structural biology carry out cancer research to accelerate the exploitation of molecular understanding of biomolecules in the advancement of novel cancer therapies.

Cancer Systems Biology
Tumorigenesis
Cancer Heterogeneity
Epidemiology
Statistical and Mechanistic Modelling of Signalling Networks

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Track 16: Molecular biology techniques

Molecular techniques are used in molecular biology, biochemistry and genetics for the analysis of DNA, RNA and protein. Molecular cloning is the widely used molecular technique. The different methods in molecular biology are Haemocytometer cell counter, Restriction enzyme digestion, DNA ligation, transfection, western blot, plasmid purification, electroporation, heat shock method and ELISA.

DNA sequencing‎
Gene delivery
Microarrays‎

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Track 17: Structural Biology Databases

A database is an organised collection of data. As a result of enormous research which is being done in Structural biology massive data has been produced. In order to assemble the data in a catalogued manner, bioinformatics databases are used. Various databases have been created to store biological data, such as sequence databases, structure databases, signalling pathway databases, etc.

A database is a structured collection of data. In the field of structural biology enormous research is being done and as a result massive data is being produced. In order to pile the data in an organized manner, bioinformatics databases are used. Various databases have been created to store biological data, such as sequence databases, structure databases, signalling pathway databases, etc. In the field of structural biology, the mainly used databases are Protein Data Bank (PDB), Electron Microscopy Data Bank, Protein Structure Classification Database (CATH) and Structural Classification of Protein (SCOP).

Classification of structural database
Classification of protein structure
Protein structure classification database
Protein data bank
Electron microscopy data bank

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Track 18: Advancements in structural Biology

Structural biology is one of the progressing fields. In the course of time many developments have been taking place. Huge numbers of solved structures have exaggerated rapidly. The field of drug design and drug discovery has been advanced. Functional annotations are another field where progressions are rapidly evolving. Alterations in order to improve the effectiveness of prevailing tools can also be noted. Remarkable advances have been made in the areas of technical imaging and advancement of hybrid methods to understand the structure and function of proteins.

Advances in Drug Design
Advances in Tool Development
Advances in Imaging Technologies

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Special Issues

Journal of Proteomics & Bioinformatics
Structural Chemistry & Crystallography Communication
Cellular and Molecular Biology

All accepted abstracts will be published in respective Conference Series LLC LTD International Journals.

Abstracts will be provided with Digital Object Identifier by Cross Ref

See more at: https://structuralbiology.expertconferences.org/

19^th International Conference on Structural Biology

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Thursday, December 19, 2019

About Conference

Conference Highlights

Special Issues